Western University researchers have demonstrated for the first time the molecular mechanisms by which cannabidiol, or CBD, blocks the psychiatric side-effects caused by tetrahydrocannabinol (THC), the main psychoactive chemical in cannabis. Let’s know more about How cannabidiol blocks the psychiatric Side effects of THC?
But First, What Is CBD, And What Is THC?
CBD is one of several cannabinoids (compounds) found in cannabis plants. CBD’s potential therapeutic applications have been investigated by researchers. Delta-9 tetrahydrocannabinol (THC) and CBD are two compounds found in marijuana. These compounds have various effects.
THC was the most well-known compound in cannabis until recently. It is the most active component and has a psychological impact. When smoked or used in cooking, it produces a mind-altering “high.” This is because THC degrades when it is heated and introduced into the body.
CBD, on the other hand, is not psychoactive. It has no effect on a person’s mental state when they use it. It does, however, have some significant medical benefits.
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How Cannabidiol Blocks The Psychiatric Side Effects Of THC
“For years we have known that strains of cannabis high in THC and low in CBD were more likely to cause psychiatric side effects. Our findings identify for the first time the molecular mechanisms by which CBD may actually block these THC-related side effects.
“Steven Laviolette, professor, Western’s Schulich School of Medicine & Dentistry
The study, published in the Journal of Neuroscience, found that rats given THC had higher levels of activated ERK, displayed more anxiety behaviors, and were more susceptible to fear-based learning. Rats that were given both CBD and THC behaved similarly to control rats: they had normal levels of activated ERK, exhibited less anxiety, and were less sensitive to fear-based learning.
Based on these findings, the researchers propose that CBD inhibits THC’s ability to overstimulate the ERK pathway in the hippocampus, thereby preventing its negative side effects.
“Our findings have important implications for cannabis prescription and long-term cannabis use. For example, individuals who are more susceptible to cannabis-related side effects should limit their use to strains with high CBD and low THC content “Laviolette stated. “More importantly, this discovery paves the way for the development of more effective and safer THC formulations.”
The study’s lead author, Ph.D. candidate, and Vanier Scholar Roger Hudson says another interesting finding was that CBD alone had no effect on the ERK pathway. “CBD had no effect on its own,” he said. “We were able to completely reverse the direction of the change on a molecular level by co-administering CBD and THC. CBD was also capable of reversing the anxiety-like and addictive-like behavior caused by THC.”
Laviolette says they will continue to identify the specific features of this molecular mechanism as part of their research. The study will look into how to make THC with fewer side effects and improve the efficacy of CBD-derived therapies.
Buying CBD can get tricky, especially for newcomers. There are quite a few things you need to keep in mind. Before purchasing, always check the product for additional ingredients. Chemicals, flavoring additives, and other compounds may not be appropriate for everyone.
Some ingredients may also cause allergic reactions in some individuals. Before purchasing any CBD product, keep an eye out for other allergens in food products and look up any unknown ingredient names. Also, always pick a brand that provides you with the complete list of ingredients and conducts independent third-party testing.
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Final Thoughts On Side Effects Of THC
So, there you go! By understanding CBD and the side effects of THC and how it works, you can understand more about what it can do for you. We hope this article has helped you know CBD and THC and their mechanisms. Stick around for more useful information on CBD!